A new first-in-human study to reduce brain injury in newborn babies after Hypoxic-Ischaemic Encephalopathy (HIE)
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ACUMEN Stands For

ACUte high dose Melatonin to improve outcomes in Encephalopathy of the Newborn

What is the
ACUMEN study?

We are researching a new treatment – melatonin, to treat babies with HIE. The ACUMEN study is a first-in-human, multi-centre study to understand the best and safest dose of melatonin we should give babies for HIE. Babies with HIE might not absorb melatonin well if taken by mouth and therefore melatonin needs to be given through a vein.  This will be the first time we will be giving this melatonin preparation to babies alongside cooling for HIE.

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Our Team

Who we are

Headed up by Professor Nikki Robertson, we are a team of Doctors, Midwives and Medical staff - Committed to improving the outcomes for babies born with HIE.

Meet The Team

Who are we?

Led by Professor Nikki Robertson at University College London (UCL) and the UCL Comprehensive Clinical Trials Unit (UCL CCTU), we are team of neonatal doctors, healthcare professionals and researchers working with families to improve outcomes for babies with HIE.

MEET THE TEAM
Acumen in Numbers...
10
Hospitals
3%
Countries
TARGET
60%
Babies

Further Reading

Useful Links
The Team
About the study
Contact
IRAS: 1011409‍
EU CT: 2025-520538-49-00

Privacy Policy

As a University, UCL uses personally-identifiable information to conduct research to improve health, care and services. As a publicly-funded organisation, we have to ensure that it is in the public interest when we use personally-identifiable information from people who have agreed to take part in research. This means that when you agree to take part in a research study, we will use your data in the ways needed to conduct and analyse the research study. Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.

Health and care research should serve the public interest, which means that we have to demonstrate that our research serves the interests of society as a whole. We do this by following the UK Policy Framework for Health and Social Care Research.

If you wish to raise a complaint on how we have handled your personal data, you can contact our Data Protection Officer who will investigate the matter. If you are not satisfied with our response or believe we are processing your personal data in a way that is not lawful you can complain to the Information Commissioner's Office (ICO).UCL's Data Protection Officer can be contacted on data-protection@ucl.ac.uk.

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