Cooling or Therapeutic Hypothermia:
Therapeutic hypothermia is a medical treatment that involves cooling a baby's body temperature to 33.5°C for 72 hours to help protect the brain. By reducing the body’s temperature, it can help slow down harmful processes and reduce the risk of further brain injury.
Dose-Escalation Study:
A study that determines the best dose of a new drug or treatment. In a dose-escalation study, the dose of the test drug is increased a little at a time in different groups of people until the highest dose that does not cause harmful side effects is found
Excipient:
Chemicals used in medicines to help keep them in soluble (liquid form)
Electroencephalography (aEEG/EEG):
a painless test that measures electrical brain activity, giving the clinician an idea of the baby’s brain function and allows monitoring of seizures (fits)
MRI:
a non-invasive medical imaging technique using magnetic fields to create detailed picture of tissues and structures. In HIE, it is used to give clinicians information of areas of injury and possible long-term prognosis
MRS:
is a non-invasive imagining technique performed during MRI to measure the chemical properties of tissues. In HIE, research has shown that it can accurately predict 2-year developmental outcomes (language, cognitive and motor). This additional scan last less than 10 mins and therefore your baby is unlikely to require any extra sedation than that already given for their standard MRI scan.
NIRS:
Near infrared spectroscopy is a painless test that uses light to measure the oxygen level of tissues.
Phase 1 Trial:
A Phase 1 trial is usually the first time that a medicine is tested in a certain human population and so it will usually investigate the safe dose range and potential side effects.
Preclinical Research:
Research done in a laboratory and/or using animals models to test a treatment before it is studied in humans.
